A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma receptors (FcgR) on human white blood cells are an integral part of the ADCC pathway. Differential response to therapeutic...

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Detalles Bibliográficos
Autores principales: Mellor, James D, Brown, Michael P, Irving, Helen R, Zalcberg, John R, Dobrovic, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549734/
https://www.ncbi.nlm.nih.gov/pubmed/23286345
http://dx.doi.org/10.1186/1756-8722-6-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549734/
https://www.ncbi.nlm.nih.gov/pubmed/23286345
http://dx.doi.org/10.1186/1756-8722-6-1

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