A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma receptors (FcgR) on human white blood cells are an integral part of the ADCC pathway. Differential response to therapeutic...

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Detalles Bibliográficos
Autores principales: Mellor, James D, Brown, Michael P, Irving, Helen R, Zalcberg, John R, Dobrovic, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549734/
https://www.ncbi.nlm.nih.gov/pubmed/23286345
http://dx.doi.org/10.1186/1756-8722-6-1
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author Mellor, James D
Brown, Michael P
Irving, Helen R
Zalcberg, John R
Dobrovic, Alexander
author_facet Mellor, James D
Brown, Michael P
Irving, Helen R
Zalcberg, John R
Dobrovic, Alexander
author_sort Mellor, James D
collection PubMed
description Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma receptors (FcgR) on human white blood cells are an integral part of the ADCC pathway. Differential response to therapeutic mAbs has been reported to correlate with specific polymorphisms in two of these genes: FCGR2A (H131R) and FCGR3A (V158F). These polymorphisms are associated with differential affinity of the receptors for mAbs. This review critically examines the current evidence for genotyping the corresponding single nucleotide polymorphisms (SNPs) to predict response to mAbs in patients with cancer.
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spelling pubmed-35497342013-01-23 A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer Mellor, James D Brown, Michael P Irving, Helen R Zalcberg, John R Dobrovic, Alexander J Hematol Oncol Review Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma receptors (FcgR) on human white blood cells are an integral part of the ADCC pathway. Differential response to therapeutic mAbs has been reported to correlate with specific polymorphisms in two of these genes: FCGR2A (H131R) and FCGR3A (V158F). These polymorphisms are associated with differential affinity of the receptors for mAbs. This review critically examines the current evidence for genotyping the corresponding single nucleotide polymorphisms (SNPs) to predict response to mAbs in patients with cancer. BioMed Central 2013-01-04 /pmc/articles/PMC3549734/ /pubmed/23286345 http://dx.doi.org/10.1186/1756-8722-6-1 Text en Copyright ©2013 Mellor et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Mellor, James D
Brown, Michael P
Irving, Helen R
Zalcberg, John R
Dobrovic, Alexander
A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
title A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
title_full A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
title_fullStr A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
title_full_unstemmed A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
title_short A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
title_sort critical review of the role of fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549734/
https://www.ncbi.nlm.nih.gov/pubmed/23286345
http://dx.doi.org/10.1186/1756-8722-6-1
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