A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants

BACKGROUND: The recently approved anti-AIDS drug rilpivirine (TMC278, Edurant) is a nonnucleoside inhibitor (NNRTI) that binds to reverse transcriptase (RT) and allosterically blocks the chemical step of DNA synthesis. In contrast to earlier NNRTIs, rilpivirine retains potency against well-character...

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Detalles Bibliográficos
Autores principales: Johnson, Barry C, Pauly, Gary T, Rai, Ganesha, Patel, Disha, Bauman, Joseph D, Baker, Heather L, Das, Kalyan, Schneider, Joel P, Maloney, David J, Arnold, Eddy, Thomas, Craig J, Hughes, Stephen H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549755/
https://www.ncbi.nlm.nih.gov/pubmed/23217210
http://dx.doi.org/10.1186/1742-4690-9-99

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549755/
https://www.ncbi.nlm.nih.gov/pubmed/23217210
http://dx.doi.org/10.1186/1742-4690-9-99

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