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A computational approach for identifying microRNA-target interactions using high-throughput CLIP and PAR-CLIP sequencing
BACKGROUND: MicroRNAs (miRNAs) play a critical role in down-regulating gene expression. By coupling with Argonaute family proteins, miRNAs bind to target sites on mRNAs and employ translational repression. A large amount of miRNA-target interactions (MTIs) have been identified by the crosslinking an...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549799/ https://www.ncbi.nlm.nih.gov/pubmed/23368412 http://dx.doi.org/10.1186/1471-2164-14-S1-S2 |