A computational approach for identifying microRNA-target interactions using high-throughput CLIP and PAR-CLIP sequencing

BACKGROUND: MicroRNAs (miRNAs) play a critical role in down-regulating gene expression. By coupling with Argonaute family proteins, miRNAs bind to target sites on mRNAs and employ translational repression. A large amount of miRNA-target interactions (MTIs) have been identified by the crosslinking an...

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Detalles Bibliográficos
Autores principales: Chou, Chih-Hung, Lin, Feng-Mao, Chou, Min-Te, Hsu, Sheng-Da, Chang, Tzu-Hao, Weng, Shun-Long, Shrestha, Sirjana, Hsiao, Chiung-Chih, Hung, Jui-Hung, Huang, Hsien-Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549799/
https://www.ncbi.nlm.nih.gov/pubmed/23368412
http://dx.doi.org/10.1186/1471-2164-14-S1-S2

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