A unified approach for allele frequency estimation, SNP detection and association studies based on pooled sequencing data using EM algorithms

BACKGROUND: Genome-wide association studies (GWAS) have identified many common polymorphisms associated with complex traits. However, these associated common variants explain only a small fraction of the phenotypic variances, leaving a substantial portion of genetic heritability unexplained. As a re...

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Detalles Bibliográficos
Autores principales: Chen, Quan, Sun, Fengzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549804/
https://www.ncbi.nlm.nih.gov/pubmed/23369070
http://dx.doi.org/10.1186/1471-2164-14-S1-S1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549804/
https://www.ncbi.nlm.nih.gov/pubmed/23369070
http://dx.doi.org/10.1186/1471-2164-14-S1-S1

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