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A unified approach for allele frequency estimation, SNP detection and association studies based on pooled sequencing data using EM algorithms
BACKGROUND: Genome-wide association studies (GWAS) have identified many common polymorphisms associated with complex traits. However, these associated common variants explain only a small fraction of the phenotypic variances, leaving a substantial portion of genetic heritability unexplained. As a re...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549804/ https://www.ncbi.nlm.nih.gov/pubmed/23369070 http://dx.doi.org/10.1186/1471-2164-14-S1-S1 |