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Sequence-only evolutionary and predicted structural features for the prediction of stability changes in protein mutants
BACKGROUND: Even a single amino acid substitution in a protein sequence may result in significant changes in protein stability, structure, and therefore in protein function as well. In the post-genomic era, computational methods for predicting stability changes from only the sequence of a protein ar...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549838/ https://www.ncbi.nlm.nih.gov/pubmed/23369338 http://dx.doi.org/10.1186/1471-2105-14-S2-S6 |