Neuroinflammation in autism spectrum disorders

OBJECTIVES: The neurobiological basis for autism remains poorly understood. However, research suggests that environmentalfactors and neuroinflammation, as well as genetic factors, are contributors. This study aims to test the role that might be played by heat shock protein (HSP)70, transforming grow...

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Autores principales: El-Ansary, Afaf, Al-Ayadhi, Laila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549857/
https://www.ncbi.nlm.nih.gov/pubmed/23231720
http://dx.doi.org/10.1186/1742-2094-9-265
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author El-Ansary, Afaf
Al-Ayadhi, Laila
author_facet El-Ansary, Afaf
Al-Ayadhi, Laila
author_sort El-Ansary, Afaf
collection PubMed
description OBJECTIVES: The neurobiological basis for autism remains poorly understood. However, research suggests that environmentalfactors and neuroinflammation, as well as genetic factors, are contributors. This study aims to test the role that might be played by heat shock protein (HSP)70, transforming growth factor (TGF)-β(2), Caspase 7 and interferon-γ (IFN-γ)in the pathophysiology of autism. MATERIALS AND METHODS: HSP70, TGF-β(2,) Caspase 7 and INF-γ as biochemical parameters related to inflammation were determined in plasma of 20 Saudi autistic male patients and compared to 19 age- and gender-matched control samples. RESULTS: The obtained data recorded that Saudi autistic patients have remarkably higher plasma HSP70, TGF-β(2,) Caspase 7 and INF-γ compared to age and gender-matched controls. INF-γ recorded the highest (67.8%) while TGF-β recorded the lowest increase (49.04%). Receiver Operating Characteristics (ROC) analysis together with predictiveness diagrams proved that the measured parameters recorded satisfactory levels of specificity and sensitivity and all could be used as predictive biomarkers. CONCLUSION: Alteration of the selected parameters confirm the role of neuroinflammation and apoptosis mechanisms in the etiology of autism together with the possibility of the use of HSP70, TGF-β(2,) Caspase 7 and INF-γ as predictive biomarkers that could be used to predict safety, efficacy of a specific suggested therapy or natural supplements, thereby providing guidance in selecting it for patients or tailoring its dose.
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spelling pubmed-35498572013-01-24 Neuroinflammation in autism spectrum disorders El-Ansary, Afaf Al-Ayadhi, Laila J Neuroinflammation Research OBJECTIVES: The neurobiological basis for autism remains poorly understood. However, research suggests that environmentalfactors and neuroinflammation, as well as genetic factors, are contributors. This study aims to test the role that might be played by heat shock protein (HSP)70, transforming growth factor (TGF)-β(2), Caspase 7 and interferon-γ (IFN-γ)in the pathophysiology of autism. MATERIALS AND METHODS: HSP70, TGF-β(2,) Caspase 7 and INF-γ as biochemical parameters related to inflammation were determined in plasma of 20 Saudi autistic male patients and compared to 19 age- and gender-matched control samples. RESULTS: The obtained data recorded that Saudi autistic patients have remarkably higher plasma HSP70, TGF-β(2,) Caspase 7 and INF-γ compared to age and gender-matched controls. INF-γ recorded the highest (67.8%) while TGF-β recorded the lowest increase (49.04%). Receiver Operating Characteristics (ROC) analysis together with predictiveness diagrams proved that the measured parameters recorded satisfactory levels of specificity and sensitivity and all could be used as predictive biomarkers. CONCLUSION: Alteration of the selected parameters confirm the role of neuroinflammation and apoptosis mechanisms in the etiology of autism together with the possibility of the use of HSP70, TGF-β(2,) Caspase 7 and INF-γ as predictive biomarkers that could be used to predict safety, efficacy of a specific suggested therapy or natural supplements, thereby providing guidance in selecting it for patients or tailoring its dose. BioMed Central 2012-12-11 /pmc/articles/PMC3549857/ /pubmed/23231720 http://dx.doi.org/10.1186/1742-2094-9-265 Text en Copyright ©2012 El-Ansary and Al-Ayadhi; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
El-Ansary, Afaf
Al-Ayadhi, Laila
Neuroinflammation in autism spectrum disorders
title Neuroinflammation in autism spectrum disorders
title_full Neuroinflammation in autism spectrum disorders
title_fullStr Neuroinflammation in autism spectrum disorders
title_full_unstemmed Neuroinflammation in autism spectrum disorders
title_short Neuroinflammation in autism spectrum disorders
title_sort neuroinflammation in autism spectrum disorders
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549857/
https://www.ncbi.nlm.nih.gov/pubmed/23231720
http://dx.doi.org/10.1186/1742-2094-9-265
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