PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

Genetic studies indicate that the mitochondrial kinase PINK1 and the RING-between-RING E3 ubiquitin ligase Parkin function in the same pathway. In concurrence, mechanistic studies show that PINK1 can recruit Parkin from the cytosol to the mitochondria, increase the ubiquitination activity of Parkin,...

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Detalles Bibliográficos
Autores principales: Lazarou, Michael, Narendra, Derek P., Jin, Seok Min, Tekle, Ephrem, Banerjee, Soojay, Youle, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549971/
https://www.ncbi.nlm.nih.gov/pubmed/23319602
http://dx.doi.org/10.1083/jcb.201210111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549971/
https://www.ncbi.nlm.nih.gov/pubmed/23319602
http://dx.doi.org/10.1083/jcb.201210111

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