A Multi-Scale Modeling Framework for Individualized, Spatiotemporal Prediction of Drug Effects and Toxicological Risk

In this study, we focus on a novel multi-scale modeling approach for spatiotemporal prediction of the distribution of substances and resulting hepatotoxicity by combining cellular models, a 2D liver model, and whole body model. As a case study, we focused on predicting human hepatotoxicity upon trea...

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Detalles Bibliográficos
Autores principales: Diaz Ochoa, Juan G., Bucher, Joachim, Péry, Alexandre R. R., Zaldivar Comenges, José M., Niklas, Jens, Mauch, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551257/
https://www.ncbi.nlm.nih.gov/pubmed/23346056
http://dx.doi.org/10.3389/fphar.2012.00204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551257/
https://www.ncbi.nlm.nih.gov/pubmed/23346056
http://dx.doi.org/10.3389/fphar.2012.00204

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