Residue-Specific Annotation of Disorder-to-Order Transition and Cathepsin Inhibition of a Propeptide-Like Crammer from D. melanogaster

Drosophila melanogaster crammer is a novel cathepsin inhibitor involved in long-term memory formation. A molten globule-to-ordered structure transition is required for cathepsin inhibition. This study reports the use of alanine scanning to probe the critical residues in the two hydrophobic cores and...

Descripción completa

Detalles Bibliográficos
Autores principales: Tseng, Tien-Sheng, Cheng, Chao-Sheng, Hsu, Shang-Te Danny, Shih, Min-Fang, He, Pei-Lin, Lyu, Ping-Chiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551606/
https://www.ncbi.nlm.nih.gov/pubmed/23349821
http://dx.doi.org/10.1371/journal.pone.0054187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551606/
https://www.ncbi.nlm.nih.gov/pubmed/23349821
http://dx.doi.org/10.1371/journal.pone.0054187

Ejemplares similares