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Residue-Specific Annotation of Disorder-to-Order Transition and Cathepsin Inhibition of a Propeptide-Like Crammer from D. melanogaster

Drosophila melanogaster crammer is a novel cathepsin inhibitor involved in long-term memory formation. A molten globule-to-ordered structure transition is required for cathepsin inhibition. This study reports the use of alanine scanning to probe the critical residues in the two hydrophobic cores and...

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Detalles Bibliográficos
Autores principales: Tseng, Tien-Sheng, Cheng, Chao-Sheng, Hsu, Shang-Te Danny, Shih, Min-Fang, He, Pei-Lin, Lyu, Ping-Chiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551606/
https://www.ncbi.nlm.nih.gov/pubmed/23349821
http://dx.doi.org/10.1371/journal.pone.0054187