Efficient one-step production of (S)-1-phenyl-1,2-ethanediol from (R)-enantiomer plus NAD(+)–NADPH in-situ regeneration using engineered Escherichia coli

BACKGROUND: Candida parapsilosis CCTCC M203011 catalyzes the stereoinversion of (R)-1-phenyl-1,2-ethanediol (PED) through oxidation and reduction. Its NAD(+)-linked (R)-carbonyl reductase (RCR) catalyzes the oxidization of (R)-PED to 2-hydroxyacetophenone (HAP), and its NADPH-dependent (S)-carbonyl...

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Detalles Bibliográficos
Autores principales: Zhang, Rongzhen, Xu, Yan, Xiao, Rong, Zhang, Botao, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551732/
https://www.ncbi.nlm.nih.gov/pubmed/23272948
http://dx.doi.org/10.1186/1475-2859-11-167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551732/
https://www.ncbi.nlm.nih.gov/pubmed/23272948
http://dx.doi.org/10.1186/1475-2859-11-167

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