Cargando…

Sildenafil restores endothelial function in the apolipoprotein E knockout mouse

BACKGROUND: Atherosclerosis is an inflammatory process of the arterial walls and is initiated by endothelial dysfunction accompanied by an imbalance in the production of reactive oxygen species (ROS) and nitric oxide (NO). Sildenafil, a selective phosphodiesterase-5 (PDE5) inhibitor used for erectil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Balarini, Camille M, Leal, Marcos A, Gomes, Isabele B S, Pereira, Thiago M C, Gava, Agata L, Meyrelles, Silvana S, Vasquez, Elisardo C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551739/ https://www.ncbi.nlm.nih.gov/pubmed/23289368 http://dx.doi.org/10.1186/1479-5876-11-3

Ejemplares similares

Inhibition of phosphodiesterase 5 restores endothelial function in renovascular hypertension
por: Dias, Ananda T, et al.
Publicado: (2014)

Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice
por: Balarini, Camille M, et al.
Publicado: (2011)

Endothelial dysfunction of resistance vessels in female apolipoprotein E-deficient mice
por: Cola, Maine S, et al.
Publicado: (2010)

Sildenafil ameliorates biomarkers of genotoxicity in an experimental model of spontaneous atherosclerosis
por: Rodrigues, Bianca P, et al.
Publicado: (2013)

Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse
por: Vasquez, Elisardo C, et al.
Publicado: (2012)

Sildenafil ameliorates oxidative stress and DNA damage in the stenotic kidneys in mice with renovascular hypertension
por: Dias, Ananda T, et al.
Publicado: (2014)

Endothelial Dysfunction in the Apolipoprotein E-deficient Mouse: insights into the influence of diet, gender and aging
por: Meyrelles, Silvana S, et al.
Publicado: (2011)

Endogenous female sex hormones delay the development of renal dysfunction in apolipoprotein E-deficient mice
por: Carneiro, Sonila S, et al.
Publicado: (2014)

Protective effect of sildenafil on the genotoxicity and cytotoxicity in apolipoprotein E-deficient mice bone marrow cells
por: Bernardes, Franciane P., et al.
Publicado: (2016)

The protective effects of oral low-dose quercetin on diabetic nephropathy in hypercholesterolemic mice
por: Gomes, Isabele B. S., et al.
Publicado: (2015)

Cardiac-Autonomic Imbalance and Baroreflex Dysfunction in the Renovascular Angiotensin-Dependent Hypertensive Mouse
por: Campagnaro, Bianca P., et al.
Publicado: (2012)

Increased Blood Pressure Variability Prior to Chronic Kidney Disease Exacerbates Renal Dysfunction in Rats
por: Freitas, Frederico F. C. T., et al.
Publicado: (2016)

Effects of Aging and Hypercholesterolemia on Oxidative Stress and DNA Damage in Bone Marrow Mononuclear Cells in Apolipoprotein E-deficient Mice
por: Tonini, Clarissa L., et al.
Publicado: (2013)

Renoprotective, anti-oxidative and anti-apoptotic effects of oral low-dose quercetin in the C57BL/6J model of diabetic nephropathy
por: Gomes, Isabele BS, et al.
Publicado: (2014)

Chronic administration of the probiotic kefir improves the endothelial function in spontaneously hypertensive rats
por: Friques, Andreia G. F., et al.
Publicado: (2015)

Mononuclear cell therapy reverts cuff-induced thrombosis in apolipoprotein E-deficient mice
por: Lima, Leandro C F, et al.
Publicado: (2012)

Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis
por: Jacinto, Thais A., et al.
Publicado: (2018)

Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects
por: Pereira, Thiago Melo Costa, et al.
Publicado: (2016)

Oral P. gingivalis infection alters the vascular reactivity in healthy and spontaneously atherosclerotic mice
por: Pereira, Raquel B, et al.
Publicado: (2011)

Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice
por: Porto, Marcella L., et al.
Publicado: (2015)

Effects of Kefir on the Cardiac Autonomic Tones and Baroreflex Sensitivity in Spontaneously Hypertensive Rats
por: Klippel, Brunella F., et al.
Publicado: (2016)

Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
por: Pereira, Thiago MC, et al.
Publicado: (2010)

The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases
por: Pereira, Thiago M. C., et al.
Publicado: (2021)

Mononuclear cell therapy attenuates atherosclerosis in apoE KO mice
por: Porto, Marcella L, et al.
Publicado: (2011)

DNA Damage and Augmented Oxidative Stress in Bone Marrow Mononuclear Cells from Angiotensin-Dependent Hypertensive Mice
por: Campagnaro, Bianca P., et al.
Publicado: (2013)

Hemodynamic Reactivity to Laboratory Stressors in Healthy Subjects: Influence of Gender and Family History of Cardiovascular Diseases
por: Simoes, Giovana M. S., et al.
Publicado: (2013)

Optimal Parameters of Laser Therapy to Improve Critical Calvarial Defects
por: Santos, Matheus AFM, et al.
Publicado: (2022)

Effects of tobacco smoking during pregnancy on oxidative stress in the umbilical cord and mononuclear blood cells of neonates
por: Rua, Ednildes de Almeida Olympio, et al.
Publicado: (2014)

Sildenafil Reduces Insulin-Resistance in Human Endothelial Cells
por: Mammi, Caterina, et al.
Publicado: (2011)

Sildenafil Inhibits the Proliferation of Cultured Human Endothelial Cells
por: Erdogan, Ali, et al.
Publicado: (2007)

Resin from Virola oleifera Protects Against Radiocontrast-Induced Nephropathy in Mice
por: Bôa, Igor Santos Fonte, et al.
Publicado: (2015)

Atherosclerosis affects calcium signalling in endothelial cells from apolipoprotein E knockout mice before plaque formation
por: Prendergast, Clodagh, et al.
Publicado: (2014)

cAMP Compartmentalization in Cerebrovascular Endothelial Cells: New Therapeutic Opportunities in Alzheimer’s Disease
por: Viña, Dolores, et al.
Publicado: (2021)

Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation
por: Ton, Alyne Mendonça Marques, et al.
Publicado: (2020)

Sildenafil Protects Endothelial Cells From Radiation-Induced Oxidative Stress
por: Wortel, R. C., et al.
Publicado: (2019)

Sildenafil suppresses the proliferation and enhances the apoptosis of hemangioma endothelial cells
por: He, Xiaopo, et al.
Publicado: (2017)

Age-Related Changes in the Behavior of Apolipoprotein E Knockout Mice
por: Fuentes, Dasha, et al.
Publicado: (2018)

Apolipoprotein E knockout rabbit model of intracranial atherosclerotic disease
por: Zabriskie, Matthew S., et al.
Publicado: (2020)

Why sildenafil and sildenafil citrate monohydrate crystals are not stable?
por: Sawatdee, Somchai, et al.
Publicado: (2015)

Atherosclerosis differentially affects calcium signalling in endothelial cells from aortic arch and thoracic aorta in Apolipoprotein E knockout mice
por: Prendergast, Clodagh, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_cpp69rhuq6dho30umtkeg7ihe3