Structural Basis of the γ-Lactone-Ring Formation in Ascorbic Acid Biosynthesis by the Senescence Marker Protein-30/Gluconolactonase

The senescence marker protein-30 (SMP30), which is also called regucalcin, exhibits gluconolactonase (GNL) activity. Biochemical and biological analyses revealed that SMP30/GNL catalyzes formation of the γ-lactone-ring of l-gulonate in the ascorbic acid biosynthesis pathway. The molecular basis of t...

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Detalles Bibliográficos
Autores principales: Aizawa, Shingo, Senda, Miki, Harada, Ayaka, Maruyama, Naoki, Ishida, Tetsuo, Aigaki, Toshiro, Ishigami, Akihito, Senda, Toshiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551927/
https://www.ncbi.nlm.nih.gov/pubmed/23349732
http://dx.doi.org/10.1371/journal.pone.0053706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551927/
https://www.ncbi.nlm.nih.gov/pubmed/23349732
http://dx.doi.org/10.1371/journal.pone.0053706

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