Cargando…

Structural Basis of the γ-Lactone-Ring Formation in Ascorbic Acid Biosynthesis by the Senescence Marker Protein-30/Gluconolactonase

The senescence marker protein-30 (SMP30), which is also called regucalcin, exhibits gluconolactonase (GNL) activity. Biochemical and biological analyses revealed that SMP30/GNL catalyzes formation of the γ-lactone-ring of l-gulonate in the ascorbic acid biosynthesis pathway. The molecular basis of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aizawa, Shingo, Senda, Miki, Harada, Ayaka, Maruyama, Naoki, Ishida, Tetsuo, Aigaki, Toshiro, Ishigami, Akihito, Senda, Toshiya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551927/ https://www.ncbi.nlm.nih.gov/pubmed/23349732 http://dx.doi.org/10.1371/journal.pone.0053706

Ejemplares similares

Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice
por: Senmaru, Takafumi, et al.
Publicado: (2012)

Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes
por: Okada, Hiroshi, et al.
Publicado: (2015)

Anaerobic crystallization of proteins
por: Senda, Miki, et al.
Publicado: (2017)

Single-cell RNA sequencing to detect age-associated genes that identify senescent cells in the liver of aged mice
por: Doshida, Yuta, et al.
Publicado: (2023)

Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis
por: Nakashima, Yu, et al.
Publicado: (2018)

Characterization of a novel type of carbonic anhydrase that acts without metal cofactors
por: Hirakawa, Yoshihisa, et al.
Publicado: (2021)

Molecular Mechanism of Strict Substrate Specificity of an Extradiol Dioxygenase, DesB, Derived from Sphingobium sp. SYK-6
por: Sugimoto, Keisuke, et al.
Publicado: (2014)

Direct Observation of Protein Microcrystals in Crystallization Buffer by Atmospheric Scanning Electron Microscopy
por: Maruyama, Yuusuke, et al.
Publicado: (2012)

Synthesis of l-Ascorbic Acid Lactone Derivatives
por: Shao, Li-Dong, et al.
Publicado: (2014)

Vitamin C deficiency causes muscle atrophy and a deterioration in physical performance
por: Takisawa, Shoko, et al.
Publicado: (2019)

Age-associated changes in the transcriptomes of non-cultured adipose-derived stem cells from young and old mice assessed via single-cell transcriptome analysis
por: Doshida, Yuta, et al.
Publicado: (2020)

Characterization of the galactono-1,4-lactone dehydrogenase from pepper fruits and its modulation in the ascorbate biosynthesis. Role of nitric oxide()
por: Rodríguez-Ruiz, Marta, et al.
Publicado: (2017)

Functional molecular evolution of a GTP sensing kinase: PI5P4Kβ
por: Takeuchi, Koh, et al.
Publicado: (2023)

Reduced Plasma Ascorbate and Increased Proportion of Dehydroascorbic Acid Levels in Patients Undergoing Hemodialysis
por: Doshida, Yuta, et al.
Publicado: (2021)

Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin
por: Watanabe-Takahashi, Miho, et al.
Publicado: (2021)

A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin
por: Watanabe-Takahashi, Miho, et al.
Publicado: (2022)

Uncovering ancient transcription systems with a novel evolutionary indicator
por: Adachi, Naruhiko, et al.
Publicado: (2016)

Biosynthesis of Sesquiterpene Lactones in Pyrethrum (Tanacetum cinerariifolium)
por: Ramirez, Aldana M., et al.
Publicado: (2013)

Biosynthesis of Ascorbic Acid in Human Beings
por: Arora, R. B.
Publicado: (1949)

Localization of Sesquiterpene Lactones Biosynthesis in Flowers of Arnica Taxa
por: Parafiniuk, Agata, et al.
Publicado: (2023)

Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis
por: Nagase, Lisa, et al.
Publicado: (2015)

Ascorbic Acid Attenuates Senescence of Human Osteoarthritic Osteoblasts
por: Burger, Maximilian G., et al.
Publicado: (2017)

The Neural Correlates of Mindful Awareness: A Possible Buffering Effect on Anxiety-Related Reduction in Subgenual Anterior Cingulate Cortex Activity
por: Hakamata, Yuko, et al.
Publicado: (2013)

Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b
por: Nishikawa, Hiroko, et al.
Publicado: (2016)

A fully automated crystallization apparatus for small protein quantities
por: Kato, Ryuichi, et al.
Publicado: (2021)

A crystal-processing machine using a deep-ultraviolet laser: application to long-wavelength native SAD experiments
por: Kawano, Yoshiaki, et al.
Publicado: (2022)

Reduced aqueous humour ascorbic-acid concentration in women with smaller anterior chamber depth
por: Ito, Sakae, et al.
Publicado: (2019)

C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes
por: Mori, Takahiro, et al.
Publicado: (2021)

Regulation of collagen biosynthesis by ascorbic acid: a review.
por: Pinnell, S. R.
Publicado: (1985)

Senescence marker protein-30/superoxide dismutase 1 double knockout mice exhibit increased oxidative stress and hepatic steatosis
por: Kondo, Yoshitaka, et al.
Publicado: (2014)

Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver
por: Kawahori, Kenichi, et al.
Publicado: (2020)

Metabolic engineering of Ashbya gossypii for deciphering the de novo biosynthesis of γ-lactones
por: Silva, Rui, et al.
Publicado: (2019)

Genetic Control of Ascorbic Acid Biosynthesis and Recycling in Horticultural Crops
por: Mellidou, Ifigeneia, et al.
Publicado: (2017)

The role of GDP-l-galactose phosphorylase in the control of ascorbate biosynthesis
por: Fenech, Mario, et al.
Publicado: (2021)

The Sesquiterpene Lactone Dehydroleucodine Triggers Senescence and Apoptosis in Association with Accumulation of DNA Damage Markers
por: Costantino, Valeria V., et al.
Publicado: (2013)

High Temperature Inhibits Ascorbate Recycling and Light Stimulation of the Ascorbate Pool in Tomato despite Increased Expression of Biosynthesis Genes
por: Massot, Capucine, et al.
Publicado: (2013)

The Association of mRNA Expression of Cell Wall Biosynthesis-Related Genes and the Reversion to Daptomycin (DAP) Susceptibility in DAP Non-Susceptible Methicillin-Resistant Staphylococcus aureus
por: Iwata, Yasunori, et al.
Publicado: (2017)

A calcium rise occurs as activating Drosophila eggs move through the female reproductive tract
por: Kaneuch, Taro, et al.
Publicado: (2015)

Efficient Biosynthesis of Acidic/Lactonic Sophorolipids and Their Application in the Remediation of Cyanobacterial Harmful Algal Blooms
por: Xia, Yuanyuan, et al.
Publicado: (2023)

Author Correction: Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver
por: Kawahori, Kenichi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vt5rf8q669gh892r0752hih5br