Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

We sought novel strategies to reduce levels of the polyglutamine androgen receptor (polyQ AR) and achieve therapeutic benefits in models of spinobulbar muscular atrophy (SBMA), a protein aggregation neurodegenerative disorder. Proteostasis of the polyQ AR is controlled by the Hsp90/Hsp70-based chape...

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Detalles Bibliográficos
Autores principales: Wang, Adrienne M., Miyata, Yoshinari, Klinedinst, Susan, Peng, Hwei-Ming, Chua, Jason P., Komiyama, Tomoko, Li, Xiaokai, Morishima, Yoshihiro, Merry, Diane E., Pratt, William B., Osawa, Yoichi, Collins, Catherine A., Gestwicki, Jason E., Lieberman, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552084/
https://www.ncbi.nlm.nih.gov/pubmed/23222885
http://dx.doi.org/10.1038/nchembio.1140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552084/
https://www.ncbi.nlm.nih.gov/pubmed/23222885
http://dx.doi.org/10.1038/nchembio.1140

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