A structural basis for streptomycin-induced misreading of the genetic code

During protein synthesis, the ribosome selects aminoacyl-tRNAs with anticodons matching the mRNA codon present in the A-site of the small ribosomal subunit. The aminoglycoside antibiotic streptomycin disrupts decoding by binding close to the site of codon recognition. Here we use X-ray crystallograp...

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Detalles Bibliográficos
Autores principales: Demirci, Hasan, Murphy, Frank, Murphy, Eileen, Gregory, Steven T., Dahlberg, Albert E., Jogl, Gerwald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552334/
https://www.ncbi.nlm.nih.gov/pubmed/23322043
http://dx.doi.org/10.1038/ncomms2346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552334/
https://www.ncbi.nlm.nih.gov/pubmed/23322043
http://dx.doi.org/10.1038/ncomms2346

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