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A structural basis for streptomycin-induced misreading of the genetic code
During protein synthesis, the ribosome selects aminoacyl-tRNAs with anticodons matching the mRNA codon present in the A-site of the small ribosomal subunit. The aminoglycoside antibiotic streptomycin disrupts decoding by binding close to the site of codon recognition. Here we use X-ray crystallograp...
Autores principales: | Demirci, Hasan, Murphy, Frank, Murphy, Eileen, Gregory, Steven T., Dahlberg, Albert E., Jogl, Gerwald |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552334/ https://www.ncbi.nlm.nih.gov/pubmed/23322043 http://dx.doi.org/10.1038/ncomms2346 |
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