NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

The neuronal RNA binding protein NOVA regulates splicing, shuttles to the cytoplasm, and co-localizes with target transcripts in dendrites, suggesting links between splicing and local translation. Here we identified >200 transcripts showing NOVA-dependent changes in abundance, but, surprisingly,...

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Detalles Bibliográficos
Autores principales: Eom, Taesun, Zhang, Chaolin, Wang, Huidong, Lay, Kenneth, Fak, John, Noebels, Jeffrey L, Darnell, Robert B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552424/
https://www.ncbi.nlm.nih.gov/pubmed/23359859
http://dx.doi.org/10.7554/eLife.00178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552424/
https://www.ncbi.nlm.nih.gov/pubmed/23359859
http://dx.doi.org/10.7554/eLife.00178

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