Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

[Image: see text] Rising drug resistance is limiting treatment options for infections by methicillin-resistant Staphylococcus aureus (MRSA). Herein we provide new evidence that wall teichoic acid (WTA) biogenesis is a remarkable antibacterial target with the capacity to destabilize the cooperative a...

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Detalles Bibliográficos
Autores principales: Farha, Maya A., Leung, Alexander, Sewell, Edward W., D’Elia, Michael A., Allison, Sarah E., Ejim, Linda, Pereira, Pedro M., Pinho, Mariana G., Wright, Gerard D., Brown, Eric D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552485/
https://www.ncbi.nlm.nih.gov/pubmed/23062620
http://dx.doi.org/10.1021/cb300413m

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552485/
https://www.ncbi.nlm.nih.gov/pubmed/23062620
http://dx.doi.org/10.1021/cb300413m

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