TSC1 Controls Distribution of Actin Fibers through Its Effect on Function of Rho Family of Small GTPases and Regulates Cell Migration and Polarity

The tumor-suppressor genes TSC1 and TSC2 are mutated in tuberous sclerosis, an autosomal dominant multisystem disorder. The gene products of TSC1 and TSC2 form a protein complex that inhibits the signaling of the mammalian target of rapamycin complex1 (mTORC1) pathway. mTORC1 is a crucial molecule i...

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Detalles Bibliográficos
Autores principales: Ohsawa, Maki, Kobayashi, Toshiyuki, Okura, Hidehiro, Igarashi, Takashi, Mizuguchi, Masashi, Hino, Okio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552859/
https://www.ncbi.nlm.nih.gov/pubmed/23355874
http://dx.doi.org/10.1371/journal.pone.0054503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552859/
https://www.ncbi.nlm.nih.gov/pubmed/23355874
http://dx.doi.org/10.1371/journal.pone.0054503

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