Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) is the third most common cause of cancer fatalities worldwide, with limited treatment options and five year survival rates of between <5 and 15%. To address this medical need, we conducted a screen of a drug-like small molecule library for HCC-selective cytotoxins....

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Detalles Bibliográficos
Autores principales: Cuconati, Andrea, Mills, Courtney, Goddard, Cally, Zhang, Xianchao, Yu, Wenquan, Guo, Haitao, Xu, Xiaodong, Block, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552860/
https://www.ncbi.nlm.nih.gov/pubmed/23355882
http://dx.doi.org/10.1371/journal.pone.0054595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552860/
https://www.ncbi.nlm.nih.gov/pubmed/23355882
http://dx.doi.org/10.1371/journal.pone.0054595

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