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Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ(42) accumulation and Caspase-3 activation
BACKGROUND: Although the mechanism of neuron loss in Alzheimer’s disease (AD) is enigmatic, it is associated with cerebral accumulation of Aβ(42). The 5XFAD mouse model of amyloid deposition expresses five familial AD (FAD) mutations that are additive in driving Aβ(42) overproduction. 5XFAD mice exh...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552866/ https://www.ncbi.nlm.nih.gov/pubmed/23316765 http://dx.doi.org/10.1186/1750-1326-8-2 |