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Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ(42) accumulation and Caspase-3 activation

BACKGROUND: Although the mechanism of neuron loss in Alzheimer’s disease (AD) is enigmatic, it is associated with cerebral accumulation of Aβ(42). The 5XFAD mouse model of amyloid deposition expresses five familial AD (FAD) mutations that are additive in driving Aβ(42) overproduction. 5XFAD mice exh...

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Detalles Bibliográficos
Autores principales:	Eimer, William A, Vassar, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552866/ https://www.ncbi.nlm.nih.gov/pubmed/23316765 http://dx.doi.org/10.1186/1750-1326-8-2

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