Resistance after Chronic Application of the HDAC-Inhibitor Valproic Acid Is Associated with Elevated Akt Activation in Renal Cell Carcinoma In Vivo

Targeted drugs have significantly improved the therapeutic options for advanced renal cell carcinoma (RCC). However, resistance often develops, negating the benefit of these agents. In the present study, the molecular mechanisms of acquired resistance towards the histone deacetylase (HDAC) inhibitor...

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Detalles Bibliográficos
Autores principales: Juengel, Eva, Makarević, Jasmina, Tsaur, Igor, Bartsch, Georg, Nelson, Karen, Haferkamp, Axel, Blaheta, Roman A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553088/
https://www.ncbi.nlm.nih.gov/pubmed/23372654
http://dx.doi.org/10.1371/journal.pone.0053100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553088/
https://www.ncbi.nlm.nih.gov/pubmed/23372654
http://dx.doi.org/10.1371/journal.pone.0053100

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