t(8;9)(p22;p24)/PCM1-JAK2 Activates SOCS2 and SOCS3 via STAT5

Fusions of the tyrosine kinase domain of JAK2 with multiple partners occur in leukemia/lymphoma where they reportedly promote JAK2-oligomerization and autonomous signalling, Affected entities are promising candidates for therapy with JAK2 signalling inhibitors. While JAK2-translocations occur in mye...

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Detalles Bibliográficos
Autores principales: Ehrentraut, Stefan, Nagel, Stefan, Scherr, Michaela E., Schneider, Björn, Quentmeier, Hilmar, Geffers, Robert, Kaufmann, Maren, Meyer, Corinna, Prochorec-Sobieszek, Monika, Ketterling, Rhett P., Knudson, Ryan A., Feldman, Andrew L., Kadin, Marshall E., Drexler, Hans G., MacLeod, Roderick A. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553112/
https://www.ncbi.nlm.nih.gov/pubmed/23372669
http://dx.doi.org/10.1371/journal.pone.0053767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553112/
https://www.ncbi.nlm.nih.gov/pubmed/23372669
http://dx.doi.org/10.1371/journal.pone.0053767

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