Nanoparticle Mediated P-Glycoprotein Silencing for Improved Drug Delivery across the Blood-Brain Barrier: A siRNA-Chitosan Approach

The blood-brain barrier (BBB), composed of tightly organized endothelial cells, limits the availability of drugs to therapeutic targets in the central nervous system. The barrier is maintained by membrane bound efflux pumps efficiently transporting specific xenobiotics back into the blood. The efflu...

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Detalles Bibliográficos
Autores principales: Malmo, Jostein, Sandvig, Axel, Vårum, Kjell M., Strand, Sabina P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553124/
https://www.ncbi.nlm.nih.gov/pubmed/23372682
http://dx.doi.org/10.1371/journal.pone.0054182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553124/
https://www.ncbi.nlm.nih.gov/pubmed/23372682
http://dx.doi.org/10.1371/journal.pone.0054182

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