Cargando…

PDK1 inhibition is a novel therapeutic target in multiple myeloma

BACKGROUND: Cancer cells utilise the glycolytic pathway even when adequate oxygen is present, a phenomenon known as the Warburg effect. We examined whether this system is operative in multiple myeloma (MM) cells and whether glycolysis inhibition is a potential therapeutic modality. METHODS: The MM c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fujiwara, S, Kawano, Y, Yuki, H, Okuno, Y, Nosaka, K, Mitsuya, H, Hata, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553526/ https://www.ncbi.nlm.nih.gov/pubmed/23321518 http://dx.doi.org/10.1038/bjc.2012.527

Ejemplares similares

PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound
por: Cen, L, et al.
Publicado: (2007)

Oncogenic role of PDK4 in human colon cancer cells
por: Leclerc, D, et al.
Publicado: (2017)

An immunohistochemical perspective of PPARβ and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours
por: Ahmed, N, et al.
Publicado: (2008)

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
por: Wigfield, S M, et al.
Publicado: (2008)

The frequency of T regulatory cells modulates the survival of multiple myeloma patients: detailed characterisation of immune status in multiple myeloma
por: Giannopoulos, K, et al.
Publicado: (2012)

Active multiple myeloma suppresses and typically eliminates coexisting MGUS
por: Campbell, John P, et al.
Publicado: (2017)

Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma
por: Jones, C I, et al.
Publicado: (2012)

GOLPH3 is a novel marker of poor prognosis and a potential therapeutic target in human renal cell carcinoma
por: Xue, Y, et al.
Publicado: (2014)

EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target
por: Iida, K, et al.
Publicado: (2011)

NY-ESO-1 antibody as a novel tumour marker of gastric cancer
por: Fujiwara, S, et al.
Publicado: (2013)

High level of interleukin-10 in serum predicts poor prognosis in multiple myeloma
por: Wang, Hua, et al.
Publicado: (2016)

MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer
por: Zhang, P, et al.
Publicado: (2017)

Increase in tumour permeability following TGF-β type I receptor-inhibitor treatment observed by dynamic contrast-enhanced MRI
por: Minowa, T, et al.
Publicado: (2009)

Inhibition of Akt sensitises neuroblastoma cells to gold(III) porphyrin 1a, a novel antitumour drug induced apoptosis and growth inhibition
por: Li, W, et al.
Publicado: (2009)

Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin–integrin signalling in head and neck squamous cell carcinoma
por: Kinoshita, T, et al.
Publicado: (2013)

EGFR mutation status in tumour-derived DNA from pleural effusion fluid is a practical basis for predicting the response to gefitinib
por: Kimura, H, et al.
Publicado: (2006)

Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma
por: Miyagaki, H, et al.
Publicado: (2012)

Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers
por: Takahashi, Y, et al.
Publicado: (2014)

Relation between outcomes and localisation of p-mTOR expression in gastric cancer
por: Murayama, T, et al.
Publicado: (2009)

Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation
por: Tanaka, M, et al.
Publicado: (2009)

Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer
por: Matsumura, T, et al.
Publicado: (2015)

Genetic instability in lung cancer: concurrent analysis of chromosomal, mini- and microsatellite instability and loss of heterozygosity
por: Ninomiya, H, et al.
Publicado: (2006)

Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling
por: Zismanov, V, et al.
Publicado: (2009)

STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells
por: Lin, H-Y, et al.
Publicado: (2013)

Molecular detection of persistent postoperative circulating tumour cells in stages II and III colon cancer patients via multiple blood sampling: prognostic significance of detection for early relapse
por: Lu, C-Y, et al.
Publicado: (2011)

Role of multidrug resistance protein 2 (MRP2) in chemoresistance and clinical outcome in oesophageal squamous cell carcinoma
por: Yamasaki, M, et al.
Publicado: (2011)

Inhibition of TGF-β and EGF pathway gene expression and migration of oral carcinoma cells by mucosa-associated lymphoid tissue 1
por: Ohyama, Y, et al.
Publicado: (2013)

Network-based analysis of calcium-binding protein genes identifies Grp94 as a target in human oral carcinogenesis
por: Nomura, H, et al.
Publicado: (2007)

Feasibility of proposed single-nucleotide polymorphisms as predictive markers for targeted regimens in metastatic colorectal cancer
por: Kim, J C, et al.
Publicado: (2013)

High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer
por: Hamano, R, et al.
Publicado: (2012)

MicroRNA-145 inhibits tumour growth and metastasis in colorectal cancer by targeting fascin-1
por: Feng, Y, et al.
Publicado: (2014)

Leucine-rich repeat-containing G-protein-coupled receptor 5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer
por: Xi, H Q, et al.
Publicado: (2014)

Insulin-like growth factor binding protein-6 inhibits prostate cancer cell proliferation: implication for anticancer effect of diethylstilbestrol in hormone refractory prostate cancer
por: Koike, H, et al.
Publicado: (2005)

microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer
por: Ueno, K, et al.
Publicado: (2013)

Multiple myeloma cells expressing low levels of CD138 have an immature phenotype and reduced sensitivity to lenalidomide
por: KAWANO, YAWARA, et al.
Publicado: (2012)

Downregulation of serum metabolite GTA-446 as a novel potential marker for early detection of colorectal cancer
por: Hata, Tsuyoshi, et al.
Publicado: (2017)

Overexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma
por: Nishimura, Y, et al.
Publicado: (2013)

MEPE/OF45 as a new target for sensitizing human tumour cells to DNA damage inducers
por: Zhang, P, et al.
Publicado: (2010)

Overexpression of FOXG1 contributes to TGF-β resistance through inhibition of p21(WAF1/CIP1) expression in ovarian cancer
por: Chan, D W, et al.
Publicado: (2009)

Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer
por: Ueo, H, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_e0beakob2uindd8vau704v66nd