Anti-prion activity of an RNA aptamer and its structural basis

Prion proteins (PrPs) cause prion diseases, such as bovine spongiform encephalopathy. The conversion of a normal cellular form (PrP(C)) of PrP into an abnormal form (PrP(Sc)) is thought to be associated with the pathogenesis. An RNA aptamer that tightly binds to and stabilizes PrP(C) is expected to...

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Detalles Bibliográficos
Autores principales: Mashima, Tsukasa, Nishikawa, Fumiko, Kamatari, Yuji O., Fujiwara, Hiromichi, Saimura, Masayuki, Nagata, Takashi, Kodaki, Tsutomu, Nishikawa, Satoshi, Kuwata, Kazuo, Katahira, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553944/
https://www.ncbi.nlm.nih.gov/pubmed/23180780
http://dx.doi.org/10.1093/nar/gks1132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553944/
https://www.ncbi.nlm.nih.gov/pubmed/23180780
http://dx.doi.org/10.1093/nar/gks1132

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