Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis

We recently reported that a guanosine-rich 40-mer DNA aptamer (LJM-3064) mediates remyelination in the Theiler’s murine encephalomyelitis virus mouse model of multiple sclerosis. Here, we characterize the G-quadruplex forms of this aptamer in vitro, and demonstrate using circular dichroism spectrosc...

Descripción completa

Detalles Bibliográficos
Autores principales: Smestad, John, Maher, L. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553947/
https://www.ncbi.nlm.nih.gov/pubmed/23175609
http://dx.doi.org/10.1093/nar/gks1093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553947/
https://www.ncbi.nlm.nih.gov/pubmed/23175609
http://dx.doi.org/10.1093/nar/gks1093

Ejemplares similares