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Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis
We recently reported that a guanosine-rich 40-mer DNA aptamer (LJM-3064) mediates remyelination in the Theiler’s murine encephalomyelitis virus mouse model of multiple sclerosis. Here, we characterize the G-quadruplex forms of this aptamer in vitro, and demonstrate using circular dichroism spectrosc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553947/ https://www.ncbi.nlm.nih.gov/pubmed/23175609 http://dx.doi.org/10.1093/nar/gks1093 |