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Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response
Telomeres cap the ends of chromosomes and regulate the replicative life span of human somatic cells. Telomere function is lost upon critical shortening and a p53-dependent checkpoint that detects altered telomere states at the G1/S transition was proposed to act as a regulator of the telomere damage...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553962/ https://www.ncbi.nlm.nih.gov/pubmed/23193277 http://dx.doi.org/10.1093/nar/gks1121 |