The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

Animal miRNAs silence the expression of mRNA targets through translational repression, deadenylation and subsequent mRNA degradation. Silencing requires association of miRNAs with an Argonaute protein and a GW182 family protein. In turn, GW182 proteins interact with poly(A)-binding protein (PABP) an...

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Detalles Bibliográficos
Autores principales: Huntzinger, Eric, Kuzuoğlu-Öztürk, Duygu, Braun, Joerg E., Eulalio, Ana, Wohlbold, Lara, Izaurralde, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553986/
https://www.ncbi.nlm.nih.gov/pubmed/23172285
http://dx.doi.org/10.1093/nar/gks1078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553986/
https://www.ncbi.nlm.nih.gov/pubmed/23172285
http://dx.doi.org/10.1093/nar/gks1078

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