The prolyl-isomerase Pin1 activates the mitochondrial death program of p53

In response to intense stress, the tumor protein p53 (p53) tumor suppressor rapidly mounts a direct mitochondrial death program that precedes transcription-mediated apoptosis. By eliminating severely damaged cells, this pathway contributes to tumor suppression as well as to cancer cell killing induc...

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Detalles Bibliográficos
Autores principales: Sorrentino, G, Mioni, M, Giorgi, C, Ruggeri, N, Pinton, P, Moll, U, Mantovani, F, Del Sal, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554345/
https://www.ncbi.nlm.nih.gov/pubmed/22935610
http://dx.doi.org/10.1038/cdd.2012.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554345/
https://www.ncbi.nlm.nih.gov/pubmed/22935610
http://dx.doi.org/10.1038/cdd.2012.112

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