Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction

The cysteine protease cathepsin K has been implicated in pathogenesis of cardiovascular disease. We hypothesized that ablation of cathepsin K protects against obesity-associated cardiac dysfunction. Wild-type mice fed a high-fat diet exhibited elevated heart weight, enlarged cardiomyocytes, increase...

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Detalles Bibliográficos
Autores principales: Hua, Yinan, Zhang, Yingmei, Dolence, Julia, Shi, Guo-Ping, Ren, Jun, Nair, Sreejayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554365/
https://www.ncbi.nlm.nih.gov/pubmed/23069627
http://dx.doi.org/10.2337/db12-0350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554365/
https://www.ncbi.nlm.nih.gov/pubmed/23069627
http://dx.doi.org/10.2337/db12-0350

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