Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status

BACKGROUND: Melanoma is the most lethal form of skin cancer, but recent advances in molecularly targeted agents against the Ras/Raf/MAPK pathway demonstrate promise as effective therapies. Despite these advances, resistance remains an issue, as illustrated recently by the clinical experience with ve...

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Detalles Bibliográficos
Autores principales: Byron, Sara A, Loch, David C, Wellens, Candice L, Wortmann, Andreas, Wu, Jiayi, Wang, John, Nomoto, Kenichi, Pollock, Pamela M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554420/
https://www.ncbi.nlm.nih.gov/pubmed/23039341
http://dx.doi.org/10.1186/1476-4598-11-75

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554420/
https://www.ncbi.nlm.nih.gov/pubmed/23039341
http://dx.doi.org/10.1186/1476-4598-11-75

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