Cargando…

Positional Bias of MHC Class I Restricted T-Cell Epitopes in Viral Antigens Is Likely due to a Bias in Conservation

The immune system rapidly responds to intracellular infections by detecting MHC class I restricted T-cell epitopes presented on infected cells. It was originally thought that viral peptides are liberated during constitutive protein turnover, but this conflicts with the observation that viral epitope...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Yohan, Yewdell, Jonathan W., Sette, Alessandro, Peters, Bjoern
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554532/
https://www.ncbi.nlm.nih.gov/pubmed/23357871
http://dx.doi.org/10.1371/journal.pcbi.1002884