Positional Bias of MHC Class I Restricted T-Cell Epitopes in Viral Antigens Is Likely due to a Bias in Conservation

The immune system rapidly responds to intracellular infections by detecting MHC class I restricted T-cell epitopes presented on infected cells. It was originally thought that viral peptides are liberated during constitutive protein turnover, but this conflicts with the observation that viral epitope...

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Detalles Bibliográficos
Autores principales: Kim, Yohan, Yewdell, Jonathan W., Sette, Alessandro, Peters, Bjoern
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554532/
https://www.ncbi.nlm.nih.gov/pubmed/23357871
http://dx.doi.org/10.1371/journal.pcbi.1002884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554532/
https://www.ncbi.nlm.nih.gov/pubmed/23357871
http://dx.doi.org/10.1371/journal.pcbi.1002884

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