Extracellular Matrix Protein Lumican Promotes Clearance and Resolution of Pseudomonas aeruginosa Keratitis in a Mouse Model

Lumican is an extracellular protein that associates with CD14 on the surface of macrophages and neutrophils, and promotes CD14-TLR4 mediated response to bacterial lipopolysaccharides (LPS). Lumican-deficient (Lum (−/−)) mice and macrophages are impaired in TLR4 signals; raising the possibility that...

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Detalles Bibliográficos
Autores principales: Shao, Hanjuan, Scott, Sherri-Gae, Nakata, Chiaki, Hamad, Abdel R., Chakravarti, Shukti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554612/
https://www.ncbi.nlm.nih.gov/pubmed/23358433
http://dx.doi.org/10.1371/journal.pone.0054765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554612/
https://www.ncbi.nlm.nih.gov/pubmed/23358433
http://dx.doi.org/10.1371/journal.pone.0054765

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