The Pharmacokinetic-Pharmacodynamic Model of Azithromycin for Lipopolysaccharide-Induced Depressive-Like Behavior in Mice

A mechanism-based model was developed to describe the time course of lipopolysaccharide-induced depressive-like behavior and azithromycin pharmacodynamics in mice. The lipopolysaccharide-induced disease progression was monitored by lipopolysaccharide, proinflammatory cytokines, and kynrenine concent...

Descripción completa

Detalles Bibliográficos
Autores principales: Hao, Kun, Qi, Qu, Hao, Haiping, Wang, Guangji, Chen, Yuancheng, Liang, Yan, Xie, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554664/
https://www.ncbi.nlm.nih.gov/pubmed/23358536
http://dx.doi.org/10.1371/journal.pone.0054981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554664/
https://www.ncbi.nlm.nih.gov/pubmed/23358536
http://dx.doi.org/10.1371/journal.pone.0054981

Ejemplares similares