Only Missense Mutations Affecting the DNA Binding Domain of P53 Influence Outcomes in Patients with Breast Carcinoma

The presence of a TP53 gene mutation can influence tumour response to some treatments, especially in breast cancer. In this study, we analysed p53 mRNA expression, LOH at 17p13 and TP53 mutations from exons 2 to 11 in 206 patients with breast carcinoma and correlated the results with disease-free an...

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Detalles Bibliográficos
Autores principales: Végran, Frédérique, Rebucci, Magali, Chevrier, Sandy, Cadouot, Muriel, Boidot, Romain, Lizard-Nacol, Sarab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554672/
https://www.ncbi.nlm.nih.gov/pubmed/23359294
http://dx.doi.org/10.1371/journal.pone.0055103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554672/
https://www.ncbi.nlm.nih.gov/pubmed/23359294
http://dx.doi.org/10.1371/journal.pone.0055103

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