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Substrate Recognition and Motion Mode Analyses of PFV Integrase in Complex with Viral DNA via Coarse-Grained Models

HIV-1 integrase (IN) is an important target in the development of drugs against the AIDS virus. Drug design based on the structure of IN was markedly hampered due to the lack of three-dimensional structure information of HIV-1 IN-viral DNA complex. The prototype foamy virus (PFV) IN has a highly fun...

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Detalles Bibliográficos
Autores principales: Hu, Jianping, Liu, Ming, Tang, Dianyong, Chang, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554684/
https://www.ncbi.nlm.nih.gov/pubmed/23365687
http://dx.doi.org/10.1371/journal.pone.0054929