Wrapping Effects within a Proposed Function-Rescue Strategy for the Y220C Oncogenic Mutation of Protein p53

Soluble proteins must protect their structural integrity from water attack by wrapping interactions which imply the clustering of nonpolar residues around the backbone hydrogen bonds. Thus, poorly wrapped hydrogen bonds constitute defects which have been identified as promoters of protein associatio...

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Detalles Bibliográficos
Autores principales: Accordino, Sebastián R., Rodríguez Fris, J. Ariel, Appignanesi, Gustavo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554699/
https://www.ncbi.nlm.nih.gov/pubmed/23365691
http://dx.doi.org/10.1371/journal.pone.0055123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554699/
https://www.ncbi.nlm.nih.gov/pubmed/23365691
http://dx.doi.org/10.1371/journal.pone.0055123

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