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Both Serum Apolipoprotein B and the Apolipoprotein B/Apolipoprotein A-I Ratio Are Associated with Carotid Intima-Media Thickness

BACKGROUND: Previous studies indicated that apolipoprotein measurements predicted cardiovascular disease (CVD) risk; however, associations between apolipoproteins and carotid intima-media thickness (CIMT) were less explored. METHODOLOGY AND PRINCIPAL FINDINGS: The cross-sectional study included 6069...

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Autores principales: Huang, Fei, Yang, Zhi, Xu, Baihui, Bi, Yufang, Xu, Min, Xu, Yu, Lu, Jieli, Liu, Yu, Dai, Meng, Zhou, Wenzhong, Wang, Weiqing, Chen, Yuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554742/
https://www.ncbi.nlm.nih.gov/pubmed/23359805
http://dx.doi.org/10.1371/journal.pone.0054628
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author Huang, Fei
Yang, Zhi
Xu, Baihui
Bi, Yufang
Xu, Min
Xu, Yu
Lu, Jieli
Liu, Yu
Dai, Meng
Zhou, Wenzhong
Wang, Weiqing
Chen, Yuhong
author_facet Huang, Fei
Yang, Zhi
Xu, Baihui
Bi, Yufang
Xu, Min
Xu, Yu
Lu, Jieli
Liu, Yu
Dai, Meng
Zhou, Wenzhong
Wang, Weiqing
Chen, Yuhong
author_sort Huang, Fei
collection PubMed
description BACKGROUND: Previous studies indicated that apolipoprotein measurements predicted cardiovascular disease (CVD) risk; however, associations between apolipoproteins and carotid intima-media thickness (CIMT) were less explored. METHODOLOGY AND PRINCIPAL FINDINGS: The cross-sectional study included 6069 participants aged 40 years or older with NGT from Shanghai, China. Serum fasting traditional lipids (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C] and triglycerides [TG]), apoA-I and apoB were assessed. A high-resolution B-mode ultrasonography was performed to measure CIMT. We found CIMT increased progressively across the quartiles of serum apoB (p for trend <0.0001). In logistic regression, concentrations of apoB (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.18–1.36), TC (OR 1.23, 95% CI 1.14–1.32), LDL-C (OR 1.25, 95% CI 1.16–1.34) and TG (OR 1.11, 95% CI 1.04–1.20) were significantly related to elevated CIMT after adjusted for age and sex. Meanwhile, the apoB/apoA-I ratio (OR 1.25, 95% CI 1.17–1.34) related to elevated CIMT. ApoB (OR 1.23, 95% CI 1.00–1.51) and the apoB/apoA-I ratio (OR 1.19, 95% CI 1.04–1.36) remained significantly associated with elevated CIMT, after adjusted for the traditional CVD risk factors including traditional lipids. CONCLUSIONS AND SIGNIFICANCE: There were significant associations between serum apoB, the apoB/apoA-I ratio and elevated CIMT. Serum apoB and the apoB/apoA-I ratio might be independent predictors of early atherosclerosis in NGT.
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spelling pubmed-35547422013-01-28 Both Serum Apolipoprotein B and the Apolipoprotein B/Apolipoprotein A-I Ratio Are Associated with Carotid Intima-Media Thickness Huang, Fei Yang, Zhi Xu, Baihui Bi, Yufang Xu, Min Xu, Yu Lu, Jieli Liu, Yu Dai, Meng Zhou, Wenzhong Wang, Weiqing Chen, Yuhong PLoS One Research Article BACKGROUND: Previous studies indicated that apolipoprotein measurements predicted cardiovascular disease (CVD) risk; however, associations between apolipoproteins and carotid intima-media thickness (CIMT) were less explored. METHODOLOGY AND PRINCIPAL FINDINGS: The cross-sectional study included 6069 participants aged 40 years or older with NGT from Shanghai, China. Serum fasting traditional lipids (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C] and triglycerides [TG]), apoA-I and apoB were assessed. A high-resolution B-mode ultrasonography was performed to measure CIMT. We found CIMT increased progressively across the quartiles of serum apoB (p for trend <0.0001). In logistic regression, concentrations of apoB (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.18–1.36), TC (OR 1.23, 95% CI 1.14–1.32), LDL-C (OR 1.25, 95% CI 1.16–1.34) and TG (OR 1.11, 95% CI 1.04–1.20) were significantly related to elevated CIMT after adjusted for age and sex. Meanwhile, the apoB/apoA-I ratio (OR 1.25, 95% CI 1.17–1.34) related to elevated CIMT. ApoB (OR 1.23, 95% CI 1.00–1.51) and the apoB/apoA-I ratio (OR 1.19, 95% CI 1.04–1.36) remained significantly associated with elevated CIMT, after adjusted for the traditional CVD risk factors including traditional lipids. CONCLUSIONS AND SIGNIFICANCE: There were significant associations between serum apoB, the apoB/apoA-I ratio and elevated CIMT. Serum apoB and the apoB/apoA-I ratio might be independent predictors of early atherosclerosis in NGT. Public Library of Science 2013-01-24 /pmc/articles/PMC3554742/ /pubmed/23359805 http://dx.doi.org/10.1371/journal.pone.0054628 Text en © 2013 Huang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Huang, Fei
Yang, Zhi
Xu, Baihui
Bi, Yufang
Xu, Min
Xu, Yu
Lu, Jieli
Liu, Yu
Dai, Meng
Zhou, Wenzhong
Wang, Weiqing
Chen, Yuhong
Both Serum Apolipoprotein B and the Apolipoprotein B/Apolipoprotein A-I Ratio Are Associated with Carotid Intima-Media Thickness
title Both Serum Apolipoprotein B and the Apolipoprotein B/Apolipoprotein A-I Ratio Are Associated with Carotid Intima-Media Thickness
title_full Both Serum Apolipoprotein B and the Apolipoprotein B/Apolipoprotein A-I Ratio Are Associated with Carotid Intima-Media Thickness
title_fullStr Both Serum Apolipoprotein B and the Apolipoprotein B/Apolipoprotein A-I Ratio Are Associated with Carotid Intima-Media Thickness
title_full_unstemmed Both Serum Apolipoprotein B and the Apolipoprotein B/Apolipoprotein A-I Ratio Are Associated with Carotid Intima-Media Thickness
title_short Both Serum Apolipoprotein B and the Apolipoprotein B/Apolipoprotein A-I Ratio Are Associated with Carotid Intima-Media Thickness
title_sort both serum apolipoprotein b and the apolipoprotein b/apolipoprotein a-i ratio are associated with carotid intima-media thickness
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554742/
https://www.ncbi.nlm.nih.gov/pubmed/23359805
http://dx.doi.org/10.1371/journal.pone.0054628
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