ACTN3 Allele Frequency in Humans Covaries with Global Latitudinal Gradient

A premature stop codon in ACTN3 resulting in α-actinin-3 deficiency (the ACTN3 577XX genotype) is common in humans and reduces strength, muscle mass, and fast-twitch fiber diameter, but increases the metabolic efficiency of skeletal muscle. Linkage disequilibrium data suggest that the ACTN3 R577X al...

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Detalles Bibliográficos
Autores principales: Friedlander, Scott M., Herrmann, Amanda L., Lowry, Daniel P., Mepham, Emily R., Lek, Monkol, North, Kathryn N., Organ, Chris L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554748/
https://www.ncbi.nlm.nih.gov/pubmed/23359641
http://dx.doi.org/10.1371/journal.pone.0052282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554748/
https://www.ncbi.nlm.nih.gov/pubmed/23359641
http://dx.doi.org/10.1371/journal.pone.0052282

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