Variation in the TLR10/TLR1/TLR6 Locus is the Major Genetic Determinant of Inter-Individual Difference in TLR1/2-Mediated Responses

Toll-like receptor (TLR)-mediated innate immune responses are important in early host defense. Using a candidate gene approach, we previously identified genetic variation within TLR1 that is associated with hyper-responsiveness to a TLR1/2 agonist in vitro and with death and organ dysfunction in pat...

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Detalles Bibliográficos
Autores principales: Mikacenic, Carmen, Reiner, Alexander P., Holden, Tarah D., Nickerson, Deborah A., Wurfel, Mark M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554851/
https://www.ncbi.nlm.nih.gov/pubmed/23151486
http://dx.doi.org/10.1038/gene.2012.53

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554851/
https://www.ncbi.nlm.nih.gov/pubmed/23151486
http://dx.doi.org/10.1038/gene.2012.53

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