Efficient production of adenovirus vector lacking genes of virus-associated RNAs that disturb cellular RNAi machinery

First-generation adenovirus vectors (FG AdVs) are widely used in basic studies and gene therapy. However, virus-associated (VA) RNAs that act as small-interference RNAs are indeed transcribed from the vector genome. These VA RNAs can trigger the innate immune response. Moreover, VA RNAs are processe...

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Detalles Bibliográficos
Autores principales: Maekawa, Aya, Pei, Zheng, Suzuki, Mariko, Fukuda, Hiromitsu, Ono, Yohei, Kondo, Saki, Saito, Izumu, Kanegae, Yumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555086/
https://www.ncbi.nlm.nih.gov/pubmed/23355950
http://dx.doi.org/10.1038/srep01136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555086/
https://www.ncbi.nlm.nih.gov/pubmed/23355950
http://dx.doi.org/10.1038/srep01136

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