Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses

The role of amyloid beta (Aβ) in brain function and in the pathogenesis of Alzheimer's disease (AD) remains elusive. Recent publications reported that an increase in Aβ concentration perturbs pre-synaptic release in hippocampal neurons. In particular, it was shown in vitro that Aβ is an endogen...

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Detalles Bibliográficos
Autores principales: Romani, Armando, Marchetti, Cristina, Bianchi, Daniela, Leinekugel, Xavier, Poirazi, Panayiota, Migliore, Michele, Marie, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555117/
https://www.ncbi.nlm.nih.gov/pubmed/23355821
http://dx.doi.org/10.3389/fncom.2013.00001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555117/
https://www.ncbi.nlm.nih.gov/pubmed/23355821
http://dx.doi.org/10.3389/fncom.2013.00001

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