Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study

PURPOSE: Opioid therapy is associated with the development of tolerance and paradoxically increased sensitivity to pain. It has been suggested that buprenorphine is associated with a higher antihyperalgesia/analgesia ratio than μ-opioid receptor agonists. The primary outcome of this study was theref...

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Detalles Bibliográficos
Autores principales: Ravn, Pernille, Secher, Erik L, Skram, Ulrik, Therkildsen, Trine, Christrup, Lona L, Werner, Mads U
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555550/
https://www.ncbi.nlm.nih.gov/pubmed/23359655
http://dx.doi.org/10.2147/JPR.S36827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555550/
https://www.ncbi.nlm.nih.gov/pubmed/23359655
http://dx.doi.org/10.2147/JPR.S36827

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